We have unique expertise and capabilities in customized DNA, RNA (including siRNA) or LNA oligonucleotide synthesis, offering both standard probe modifications (TaqMan Probes, different dyes, fluorophores and internal or terminal quenchers, oligo branching and click chemistry) and special modifications (azides, alkynes trans cyclooctenes, unorthodox dyes, modified bases -2′-O-Methyl, 2′-Fluoro, LNA) with large scale production capability.
At DIANA Biotechnologies, we deliver top-quality custom oligonucleotides tailored to your needs—whether DNA, RNA (siRNA), or LNA. With a wide range of modifications, from TaqMan Probes to specialized bases and dyes, we guarantee the highest purity, quality, and yield at highly competitive prices.
Not sure which modification fits your project? Our team of experts is here to help! With personalized support, we’ll guide you through selecting the perfect dyes, quenchers, or modifications. Just fill out our form, and we'll get back to you right away with the answers you need!
Technology
siRNAs are used in molecular biology to silence gene expression post-transcriptionally and are widely used in functional genomics studies, therapeutic development, and drug target validation. Their ability to selectively silence genes makes siRNAs a powerful tool for understanding gene function and developing treatments for various diseases, including cancers, viral infections, and genetic disorders.
LNA’s unique chemical structure enhances the thermal stability and binding affinity to their complementary DNA or RNA sequences resulting in increased specificity and resistance to nuclease degradation compared to traditional DNA or RNA molecules. These properties make LNAs highly effective in applications such as antisense therapy, gene silencing, microRNA research, and in situ hybridization. Additionally, LNA probes are used in quantitative PCR (qPCR) assays to improve detection sensitivity and accuracy. Increased maximum annealing temperature and improved specifity and affinity in base-pairing
TaqMan™ probes is a key technology to your PCR assays providing high specificity, sensitivity, and quantification accuracy making them indispensable in research and diagnostics. We offer a wide range of dyes and quenchers at a highy competitive price.
Thiol Chemistry Modifiers: Maleinimid, Vinyl sulfons, thiol modified 5′ end
Click Chemistry: Copper catalyzed clicked reaction, copper-free chemistry, Alkyne, Azide, PEGn-alkyne, PEGn-Azide
Spacers: Both internal and terminal with any desired lenght
NHS Reactive Modifiers: Aminomodifiers, both ends or internal
Non-standard bases: Terminator bases (either fluoro or deoxy)
All modifications listed can be performed on the 3′ end, 5′ end or internally.
Do you have any doubts of how to use your oligonucleotides? Are you unsure which dye or quencher you need to use? Our team of experts is here to help you. We offer a highly professional and flexible support! Fill out our form with everything you need to know about oligonucleotides and their applications and we will reach you immediately!
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